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Alternatively, for patients who do not tolerate the 10 mg dose well, either discontinuation of the drug or a dose of 5 mg orally once a day may be appropriate (depending on the severity of the adverse reaction to the 10 mg dose). Dialysis. The manufacturer of sibutramine does not recommend its use in patients with severe renal dysfunction.
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Sibutramine has been recently withdrawn from the market in many countries due to the negative side effects that it produces which include increased cardiovascular events and strokes. Legally it was only allowed in prescription medicines at a maximum level of 15mg however some of the illegal slimming products have been found to contain …
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Sibutramine is a monoamine reuptake inhibitor (MRI) that, in humans, reduces the reuptake of norepinephrine (by ~73%), serotonin (by ~54%), and dopamine (by ~16%), thereby increasing the levels of these substances in synaptic clefts and helping enhance satiety; the serotonergic action, in particular, is thought to influence appetite.Older anorectic agents such as amphetamine and fenfluramine …